Amniotic Membrane-Derived Treatment

What is amniotic membrane-derived treatment?

Amniotic fluid contains multiple excellent properties for promoting tissue regeneration and repair. The fluid contains growth factors which can help promote new tissue growth and also help to call in the body’s stem cells. Amniotic fluid also contains important anti-inflammatory properties from biochemicals called cytokines that help relieve pain.

Amniotic fluid is heavily concentrated in important healing molecules, growth factors, hyaluronic acid, antimicrobial components, and stem cell activators that are able to work in an anyone’s body without producing an immunologic rejection response, often making it an ideal biologic treatment option either alone or used with other biologic treatment modalities.

At Hudson Medical, we use Zimmer Biomet® Amnioflo® (Zimmer Biomet® MiMedX® PURION processed dehydrated Human Amnion/Chorion Membrane dHACM).


Amniotic and chorionic products have been used successfully for over a century in the setting of problematic tissue healing and have enjoyed a stellar safety record. Following recent clinical success with treating orthopedic pain and injuries, there has been renewed interest in the use of allograft tissue treatments for musculoskeletal disease and injury.

How amniotic membrane-derived treatment works

Hyaluronic acid injections include a naturally-occurring substance found in the synovial fluid, which lubricates the cartilage and reduces friction in the joint. Amniotic fluid, which is similar to synovial fluid in its ability to protect and lubricate, also provides cushioning for the knee much the same way as it cushions the fetus.

Amnioflo® contains 226 known regulators of healing and inflammation. Once re-hydrated, this medium of beneficial molecules can enhance the tissue healing environment by stimulating proliferation of progenitor cells. These biologic facilitators help encourage tissue growth and healing. Components of the extracellular matrices can incorporate into natural scaffolds that may accelerate healing while limiting scar formation.

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