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What Are the Therapeutic Potentials of Exosomes and How Are They Being Used Currently?

What Are the Therapeutic Potentials of Exosomes and How Are They Being Used Currently?

Researchers study exosomes for their possible benefit in a multitude of medical specialties, including neurology, immunology, rheumatology, oncology, hematology, orthopedics, and others. Akin to “genetic gold,” they infuse everything in their vicinity with growth potential. They have been shown to grow skin cells to repair burns, cartilage to restore joint damage, and hair cells to restore hair loss. They can also induce the growth of new blood vessels (a process known as “angiogenesis”) in targeted areas, which can improve sexual function.

How Are Exosomes Being Used Currently?

One of the most exciting uses of exosomes currently involves chronic pain management. Patients find that exosome treatments can help relieve their chronic pain from knee osteoarthritis and other debilitating orthopedic conditions.

At Hudson Medical + Wellness, we are currently investigating the use of exosomes to help our patients who suffer from chronic neck or back pain. The exosomes that we use are derived from human bone marrow stem cells. Similar to stem cell therapies, exosomes can be injected locally to help with targeted pain relief, but they also may be valuable when injected into the epidural space. Our clinical trial will help us learn more valuable information about this type of therapy.

How Can I Learn More About Exosomes?

At Hudson Medical + Wellness, we are keenly interested in the benefits of exosomes, alone or in addition to our other minimally invasive pain-relieving technologies such as platelet-rich plasma (PRP) therapy.

If you are interested in learning more about exosome therapies, schedule a consultation with one of our Pain Management and Regenerative Medicine specialists today.

References:

D’Arrigo D, Roffi A, Cucchiarini M, Moretti M, Candrian C, Filardo G. Secretome and Extracellular Vesicles as New Biological Therapies for Knee Osteoarthritis: A Systematic Review. J Clin Med. 2019;8(11):1867. Published 2019 Nov 4. doi: 10.3390/jcm8111867

Egger A, Tomic-Canic M, Tosti A. Advances in Stem Cell-Based Therapy for Hair Loss. CellR4 Repair Replace Regen Reprogram. 2020;8:e2894.

Han C, Sun X, Liu L, et al. Exosomes and Their Therapeutic Potentials of Stem Cells. Stem Cells Int. 2016;2016:7653489. doi: 10.1155/2016/7653489

Hu P, Yang Q, Wang Q, et al. Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration [published correction appears in Burns Trauma. 2020 Jan 23;8:tkaa007]. Burns Trauma. 2019;7:38. Published 2019 Dec 26. doi: 10.1186/s41038-019-0178-8

Li JJ, Hosseini-Beheshti E, Grau GE, Zreiqat H, Little CB. Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Nanomaterials (Basel). 2019;9(2):261. Published 2019 Feb 14. doi: 10.3390/nano9020261

Ouyang X, Han X, Chen Z, Fang J, Huang X, Wei H. MSC-derived exosomes ameliorate erectile dysfunction by alleviation of corpus cavernosum smooth muscle apoptosis in a rat model of cavernous nerve injury. Stem Cell Res Ther. 2018 Sep 26;9(1):246. doi: 10.1186/s13287-018-1003-1

Vonk LA, van Dooremalen SFJ, Liv N, et al. Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro. Theranostics. 2018;8(4):906-920. doi: 10.7150/thno.20746

Zhang, Y., Liu, Y., Liu, H. et al. Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci 9, 19 (2019). https://doi.org/10.1186/s13578-019-0282-

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